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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CDC25B All Species: 22.12
Human Site: Y396 Identified Species: 54.07
UniProt: P30305 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P30305 NP_004349.1 580 64987 Y396 H R E L I G D Y S K A F L L Q
Chimpanzee Pan troglodytes XP_514487 626 69996 Y396 H R E L I G D Y S K A F L L Q
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_850186 574 64910 Y390 H R E L I G D Y S K A F L L Q
Cat Felis silvestris
Mouse Mus musculus P30306 576 65472 Y392 H R G L I G D Y S K A F L L Q
Rat Rattus norvegicus P48966 574 64268 Y390 H R G L I G D Y S K A F L L Q
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507389 566 64832 Y382 R R E L I G D Y S K A Y L L Q
Chicken Gallus gallus XP_418479 526 59350 F349 D F S K G Y L F H T V D G K H
Frog Xenopus laevis P30310 599 67627 F415 H R Q L I G D F S K V Y A L P
Zebra Danio Brachydanio rerio NP_001108567 563 63619 F379 P S N V I G D F T K A P A L P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P20483 479 54076 S302 R D L K S I S S E T V A R L L
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 92 N.A. 85.1 N.A. 81.2 79.8 N.A. 63.7 43.7 34.2 45.3 N.A. 25.3 N.A. N.A. N.A.
Protein Similarity: 100 92.1 N.A. 90.1 N.A. 88.4 85.6 N.A. 76.5 61.2 51 63.6 N.A. 41.7 N.A. N.A. N.A.
P-Site Identity: 100 100 N.A. 100 N.A. 93.3 93.3 N.A. 86.6 0 60 40 N.A. 6.6 N.A. N.A. N.A.
P-Site Similarity: 100 100 N.A. 100 N.A. 93.3 93.3 N.A. 93.3 6.6 80 60 N.A. 6.6 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 70 10 20 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 10 10 0 0 0 0 80 0 0 0 0 10 0 0 0 % D
% Glu: 0 0 40 0 0 0 0 0 10 0 0 0 0 0 0 % E
% Phe: 0 10 0 0 0 0 0 30 0 0 0 50 0 0 0 % F
% Gly: 0 0 20 0 10 80 0 0 0 0 0 0 10 0 0 % G
% His: 60 0 0 0 0 0 0 0 10 0 0 0 0 0 10 % H
% Ile: 0 0 0 0 80 10 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 20 0 0 0 0 0 80 0 0 0 10 0 % K
% Leu: 0 0 10 70 0 0 10 0 0 0 0 0 60 90 10 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 10 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 10 0 0 0 0 0 0 0 0 0 0 10 0 0 20 % P
% Gln: 0 0 10 0 0 0 0 0 0 0 0 0 0 0 60 % Q
% Arg: 20 70 0 0 0 0 0 0 0 0 0 0 10 0 0 % R
% Ser: 0 10 10 0 10 0 10 10 70 0 0 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 0 10 20 0 0 0 0 0 % T
% Val: 0 0 0 10 0 0 0 0 0 0 30 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 10 0 60 0 0 0 20 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _